摘要 :
The cerebral cortex contains two main neuronal cell populations: the excitatory pyramidal neurons and the inhibitory interneurons, which constitute 20-30% of all cortical neurons. Cortical inter neurons are characterized by a rema...
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The cerebral cortex contains two main neuronal cell populations: the excitatory pyramidal neurons and the inhibitory interneurons, which constitute 20-30% of all cortical neurons. Cortical inter neurons are characterized by a remarkable morphological, molecular and functional diversity. A swathe of research activity over the last 20 years has sought to determine how cortical interneurons acquire their mature cellular and functional features, and has identified a number of transcription factors that func- tion at different stages of interneuron development. Here, we review all current knowledge concerning the multiple functions of the "master regulator" LIM-Homeodomain transcription factor Lhx6 a gene expressed in the medial ganglionic eminence of the basal telencephalon that controls the development of somatostatin and parvalbumin expressing interneurons.
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摘要 :
Objective Neural projections from the ventral hippocampal CA1 (vCA1) to the medial prefrontal cortex (mPFC) and from the posterior dorsal hippocampal CA1 (pdCA1) to the mPFC are important for information processing. Previous studi...
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Objective Neural projections from the ventral hippocampal CA1 (vCA1) to the medial prefrontal cortex (mPFC) and from the posterior dorsal hippocampal CA1 (pdCA1) to the mPFC are important for information processing. Previous studies have revealed that two forms of long-term synaptic plasticity, long-term potentiation (LTP) and long-term depression (LTD), and gamma oscillations, which are all believed to be neural bases for learning and memory in the vCA1-mPFC and the pdCA1-mPFC pathways, exhibited distinct profiles. However, the underlying mechanism is unclear. Methods In the present study, amperometric cholinergic signals were monitored during in-vivo electrophysiological recordings of evoked extracellular postsynaptic potentials and spontaneous local field potentials. Results The results demonstrated that in the vCA1-mPFC pathway, increased cholinergic currents and gamma power of the amperometric cholinergic signals were accompanied by the induction of LTD and increased gamma power of local field potentials, whereas, in the pdCA1-mPFC pathway, decreased cholinergic currents and increased gamma power of the amperometric cholinergic signals were accompanied by the induction of LTP and increased gamma power of local field potentials. Conclusion These findings indicated that some correlations may exist between amperometric cholinergic signals and synaptic plasticity in the hippocampus-mPFC pathway. The pattern of alterations in cholinergic signals may help to illustrate the specific properties of synaptic plasticity and gamma oscillations in the vCA1-mPFC and the pdCA1-mPFC pathways.
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